Plasma cholesteryl ester transfer protein (Cetp) and carotid intima-media thickness in european indivduals at high cardiovascular risk
Poster
Data di Pubblicazione:
2012
Citazione:
Plasma cholesteryl ester transfer protein (Cetp) and carotid intima-media thickness in european indivduals at high cardiovascular risk / S. Simonelli, D. Baldassarre, M. Amato, S. Catelnuovo, B. Frigerio, A. Ravani, D. Sansaro, F. Veglia, G. Franceschini, E. Tremoli, L. Calabresi. - In: GIORNALE ITALIANO DELL'ARTERIOSCLEROSI. - ISSN 2240-4821. - (2012), pp. 79-79. (Intervento presentato al 26. convegno Congresso Nazionale della Società Italiana per lo Studio dell’Arteriosclerosi tenutosi a Roma nel 2012).
Abstract:
Cholesteryl ester transfer protein (CETP) is a plasma glycoprotein that is bound mainly to HDL particles and mediates the transfer of neutral lipids (CE and TG) between HDL and apoB-containing lipoproteins (LDL and VLDL). Inhibition of CETP is considered a potential approach to treat dyslipidemia; however, discussion regarding CETP inhibition as a potential strategy for prevention of atherosclerosis has been controversial. As the role of CETP in the atherogenic process is still not fully clarified, we studied the association of CETP concentration with intima-media thickness of the carotid artery (IMT) in subjects with high cardiovascular risk and free of any pharmacological treatments. The plasma CETP concentration was measured by an immunoenzymatic assay developed in our laboratory in a subgroup (n=540) of subjects enrolled in the multicenter, longitudinal, observational IMPROVE study. Mean and maximum IMT of the whole carotid tree was measured by B-mode ultrasonography in all subjects. In the entire cohort, CETP quartiles were not associated with carotid mean and maximum IMT (P for trend 0.64 and 0.66, respectively), also after adjustment for age, gender, HDL-C, and triglycerides. In the whole group of examined subjects, plasma CETP concentration correlated positively with HDL-C (P< 0.0001). The present findings show that in European individuals at high cardiovascular risk CETP concentration is not a major determinant of carotid IMT.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. Simonelli, D. Baldassarre, M. Amato, S. Catelnuovo, B. Frigerio, A. Ravani, D. Sansaro, F. Veglia, G. Franceschini, E. Tremoli, L. Calabresi
Link alla scheda completa: