Data di Pubblicazione:
1999
Citazione:
Stereoselective synthesis of 2-azetidinones as cholesterol-absorption inhibitors / R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 10:24(1999), pp. 4841-4849. [10.1016/S0957-4166(99)00566-2]
Abstract:
The synthesis of two 2-azetidinones possessing powerful cholesterol- absorption inhibition properties has been accomplished by a short and highly stereoselective reaction sequence. The key step is the condensation of the titanium enolate of the easily prepared 2-pyridylthioester (R)-11 with imine 6 which affords the desired β-lactam intermediate in the correct relative and absolute configuration. Conversion to the pharmacologically active compounds is readily accomplished by simple functional group manipulation. (C) 2000 Elsevier Science Ltd.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi
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