Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I : synthesis
Articolo
Data di Pubblicazione:
2012
Citazione:
Homo- and heterodimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part I : synthesis / L. Manzoni, L. Belvisi, A. Bianchi, A. Conti, C. Drago, M. de Matteo, L. Ferrante, E. Mastrangelo, P. Perego, D. Potenza, C. Scolastico, F. Servida, G. Timpano, F. Vasile, V. Rizzo, P. Seneci. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 20:22(2012), pp. 6687-6708.
Abstract:
Novel pro-apoptotic, homo- and heterodimeric Smac mimetics/IAPs inhibitors based on the N-AVPI-like 4-substituted 1-aza-2-oxobicyclo[5.3.0]decane scaffold were prepared from monomeric structures connected through a head-head (8), tail-tail (9) or head-tail (10) linker. The selection of appropriate decorating functions for the scaffolds, and of rigid and flexible linkers connecting them, is described. The synthesis, purification and analytical characterization of each prepared dimer 8-10 is thoroughly described.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
apoptosis; IAP inhibitors; oncology; peptidomimetics; Smac mimetics
Elenco autori:
L. Manzoni, L. Belvisi, A. Bianchi, A. Conti, C. Drago, M. de Matteo, L. Ferrante, E. Mastrangelo, P. Perego, D. Potenza, C. Scolastico, F. Servida, G. Timpano, F. Vasile, V. Rizzo, P. Seneci
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