Data di Pubblicazione:
2008
Citazione:
IMPACT OF KIT MUTATIONS IN ACUTE MYELOID LEUKAEMIA WITH INV(16) / R.C. Cairoli, A. Beghini, C.B. Ripamonti, G. Grillo, G. Nadali, E. Di Bona, P. Colapietro, G.B. Bertani, E. Ravelli, G. Nador, C. Castagnola, C. Cattaneo, E. Ottaviani, P. Pioltelli, A. Viola, A. Cuneo, F. Ferrara, G. Martinelli, M. Lazzarino, G. Rossi, G. Pizzolo, E. Morra. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 93:Suppl. 1(2008), pp. 16-16. ((Intervento presentato al 13. convegno Congress of the European-Hematology-Association tenutosi a Copenhagen nel 2008.
Abstract:
Several studies have recently pointed out the adverse
impact of KIT mutations (mutKIT) on relapse incidence (RI) and overall
survival (OS) in patients with t(8;21) AML. By contrast, the prognostic
significance of mutKIT in patients with inv(16) remains unclear. Aims.
Purpose of this study is to evaluate the prevalence and the effect on outcome
of mutKIT in inv(16)(p13q22). Patients and Methods. 50 adults with
inv(16) AML at diagnosis (median age 46.6 years, range: 17-88; M/F: 30
/20), were centrally analyzed for mutKIT in exon 2, 8, 10, 11 and 17.
Mutations were detected using sequencing and other sensitive assays
such as ARMS (amplification refractory mutation system) PCR for
D816Y and D816H, enzymatic digestion with HINFI for D816V and
with Tsp509I for N822K. Results. KIT mutations were documented in
17/50 patients (34%). Among the mutKIT cases, we detected mutations
in exon 17 (n=12), exon 8 (n= 4) and exon 10 (n=1). We found no significant
difference between the mutKIT vs the unmutated (KIT-) patients
in WBC count at presentation (WBC 13.9x109/Liter, range 4.4 to 277.5
vs 19.4x109/Liter, range 2.5 to 130; Mann-Whitney U test: p=0.649). 42
patients (age <60 years) received intensive chemotherapy; of them, 13
resulted mutKIT upon mutational screening. CR was achieved in 13 of
13 mutKIT patients (100%) vs 27 of 29 KIT-patients (93%), (Fisher’s
exact test: p>0.999). With a median follow-up of 26 months (range: 2 to
147), the Kaplan-Meier plots showed a worse RI among the mutKIT vs
the KIT- patients (log-rank test: p=0.04; Figure 1). We didn't observe any
difference in OS between the two groups of patients (log-rank test:
p=0.44).
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R.C. Cairoli, A. Beghini, C.B. Ripamonti, G. Grillo, G. Nadali, E. Di Bona, P. Colapietro, G.B. Bertani, E. Ravelli, G. Nador, C. Castagnola, C. Cattaneo, E. Ottaviani, P. Pioltelli, A. Viola, A. Cuneo, F. Ferrara, G. Martinelli, M. Lazzarino, G. Rossi, G. Pizzolo, E. Morra
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