Clinical and immunological effects of the long term dietary supplementation with a probiotic fermented milk in pre-school children allergic to inhalants
Abstract
Data di Pubblicazione:
2006
Citazione:
Clinical and immunological effects of the long term dietary supplementation with a probiotic fermented milk in pre-school children allergic to inhalants / F. Salvini, L. Morelli, A. Ruscitto, G. Radaelli, D. Cattivelli, C. Agostoni, M. Giovannini. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - 165:Suppl. 1(2006), pp. 114-114. ((Intervento presentato al convegno Pre Congress Satellite Symposium tenutosi a Barcelona nel 2006 [10.1007/s00431-006-0349-z].
Abstract:
Background and Aims: Probiotics may have
immunomodulatory functions, exerting beneficial
effects in allergic disease. We investigated whether
prolonged daily consumption of Lactobacillus casei DN-
114 001 fermented milk improve clinical and
immunological condition of children aged 3-6 years
allergic to inhalants.
Methods: In a randomised-controlled multicentric trial
patients were randomly assigned to receive for one year
100 ml per day of L. casei DN-114 001 fermented milk
(109 cells/ml), or no probiotics (controls). Clinical
evaluations occurred every 3 months. Faecal flora
composition was assessed every 6 months (30 treated,
15 controls). Outcome measures were allergy-related
signs incidence, infections incidence/severity, IgE-G-A
serological levels (baseline vs 12 months).
Results: Participants (187; 92 treated) were similar
regarding gestational age, breastfeeding, family
smokers, pets, siblings, day-care admission.
Supplemented children exibited less rhinitis episodes
than controls up to T6 [mean-SD: 0,6 (1) vs 0,9 (1,1) at
T3, p= 0,031; 1 (2,6) vs 1,6 (2) at T6, p=0,027]. Asthma
and infections incidence/severity did not differ between
groups. IgE mean % variation increased in controls at
T12 vs baseline (+ 25%; p< 0,01) but not in the treated
group (+8%; p=0,59). IgG and IgA mean % variation
significantly increased in treated group (+6,3% and
+11,5% respectively; p< 0,01) but not in controls (2,4%
and 3,7% respectively; p=0,34 and 0,19). Faecal
analysis showed Lactobacillus casei DN-114 001 in the
gut flora of 78% of supplemented children through the
study period.
Conclusions: Long-term daily consumption of
Lactobacillus Casei DN-114 001 fermented milk may
positively influence on the clinical and immunological
status of allergic children
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Diabetes mellitus; Epidemiology; Infant nutrition; Risk factors; Type 1
Elenco autori:
F. Salvini, L. Morelli, A. Ruscitto, G. Radaelli, D. Cattivelli, C. Agostoni, M. Giovannini
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