Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis : a controlled randomized study
Articolo
Data di Pubblicazione:
1992
Citazione:
Superovulation with human menopausal gonadotropins in the treatment of infertility associated with minimal or mild endometriosis : a controlled randomized study / L. Fedele, S. Bianchi, M. Marchini, L. Villa, D. Brioschi, F. Parazzini. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 58:1(1992 Jul), pp. 28-31. [10.1016/S0015-0282(16)55132-2]
Abstract:
Objective: To determine the efficacy of superovulation with buserelin acetate, human menopausal gonadotropins (hMG), and human chorionic gonadotropin (hCG) in the treatment of infertility associated with minimal or mild endometriosis.
Design: Prospective, randomized, controlled study.
Subjects: Forty-nine infertile women with a laparoscopic diagnosis of endometriosis stage I (n = 29) or II (n = 20) according to the revised American Fertility Society classification, randomly assigned to three superovulation cycles (n = 24) or 6 months' expectant management (n = 25).
Main Outcome Measures: Cycle fecundity rates and cumulative pregnancy rates (CPR) in the two groups.
Results: Nine pregnancies were obtained in the superovulation-treated patients and six in the nontreated ones. The cycle fecundity rates and CPR were 0.15% and 37.4% after three superovulation cycles and 0.045% and 24% after 6 months of expectant management (P < 0.05 and P = not significant, respectively). The women who did not achieve a pregnancy after three cycles of superovulation were followed for a total of 50 months during which no therapy was given. One pregnancy started in this period (cycle fecundity rate = 0.020). One spontaneous abortion occurred in each group. Three treated patients had multiple pregnancies, and four had ovarian hyperstimulation syndrome.
Conclusion: Superovulation seems to be associated with a better cycle fecundity rate but not a better CPR than expectant management in infertile women with endometriosis stages I and II. The efficacy and side effects of this therapeutic approach should be evaluated in larger series.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
endometriosis; fertility; human gonadotropins; Superovulation
Elenco autori:
L. Fedele, S. Bianchi, M. Marchini, L. Villa, D. Brioschi, F. Parazzini
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