Approved medication of water with enrofloxacin to treat turkey colibacillosis : assessment of efficacy using a PK/PD approach
Articolo
Data di Pubblicazione:
2012
Citazione:
Approved medication of water with enrofloxacin to treat turkey colibacillosis : assessment of efficacy using a PK/PD approach / E. Russo, L. Lucatello, D. Giovanardi, P. Cagnardi, G. Ortali, V. Di Leva, C. Montesissa. - In: VETERINARY MICROBIOLOGY. - ISSN 0378-1135. - 161:1-2(2012 Dec 28), pp. 206-212. [10.1016/j.vetmic.2012.07.028]
Abstract:
The efficacy of administering enrofloxacin at 10 mg/kg in medicated water to turkeys was
evaluated by applying a PK/PD approach to the kinetic parameters obtained after oral
pulsed administration and to the MIC values of avian pathogenic Escherichia coli (APEC)
strains isolated from commercial turkey flocks.
The kinetic parameters of enrofloxacin were evaluated in 10 healthy and 10
colisepticemic turkeys that received the drug dissolved in medicated water at 89 mg/
mL and 71 mg/mL, respectively, for 10 h/day for 5 days. Blood samples were collected for
24 h from all turkeys on the last day of treatment, and the serum was analysed by HPLC
with fluorimetric detection.
The mean AUC (7374.53 1067.64 h ng/mL and 7656.95 1460.61 h ng/mL) and Cmax
values (673.09 186.18 ng/mL and 543.50 68.75 ng/mL) obtained for healthy and sick
turkeys were not significantly different. High-level resistance was observed in 30.3% of strains,
40.5% exhibited intermediate resistance, and only 29.2% were susceptible; the MIC50 and
MIC90 values were 1 mg/L and 32 mg/L, respectively. The PK/PD parameters Cmax/MIC50 (0.67
and 0.54 for healthy and sick turkeys, respectively) and AUC/MIC50 (7.37 and 7.66) were lower
than the efficacy breakpoints reported for fluoroquinolones. These results indicate that
authorised dosage of enrofloxacin used in pulsed medicated water administration could be
ineffective against more than the 70% of circulating APEC strains, indicating the need to test
the drug susceptibility of APEC prior to administering the drug and adopting a more
convenient medication schedule for mass treatment
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Avian pathogenic Escherichia coli; Enrofloxacin; PK/PD; Turkey
Elenco autori:
E. Russo, L. Lucatello, D. Giovanardi, P. Cagnardi, G. Ortali, V. Di Leva, C. Montesissa
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