Data di Pubblicazione:
2009
Citazione:
Light or regular cigarettes consumption: effect on endothelial function / B. Frigerio, S. Castelnuovo, M. Amato, A. Ravani, E. Tremoli, C. Sirtori, D. Baldassarre. ((Intervento presentato al 8. convegno INTERNATIONAL CONGRESS ON CORONARY ARTERY DISEASE: FROM PREVENTION TO INTERVENTION (ICCAD) tenutosi a Praga nel 2009.
Abstract:
Objective: To evaluate whether the effect of chronic or acute cigarette smoking on endothelial
function is related to the cigarette content of tar, nicotine or carbon-monoxide (CO) reported on the
pack.
Methods: Cigarettes were defined as light or regular on the basis of the concomitant presence of tar,
nicotine and CO above or below 7, 0.7, 7 mg, respectively. Brachial artery flow mediated dilation
(FMD) of 45 consumers of light cigarettes was compared to that of 45 consumers of regular
cigarettes, matched for age, gender and pack-years. Forty-five never smokers, matched for age and
gender, were included as negative controls. The acute effect of a light or regular cigarette on FMD
was assessed in 81 smokers, who were asked to smoke a single light (n=52) or regular (n=29)
cigarette. In these subjects, FMD was measured before and 10 minutes after the single cigarette
smoking.
Results: FMD of light (2.78±3.13%) and regular (4.03±2.93%) cigarettes consumers were lower than
in never smokers (6.26%±3.21; both p< 0.002). In contrast, no difference was observed when light
and regular cigarettes consumers were compared (p=0.173). A single cigarette smoking caused an
FMD reduction of about 39% (p< 0.0001), but also in this case, no difference was detectable
comparing light or regular cigarettes (-36.9% vs. -47.0%, respectively; p=0.168).
Conclusions: Consumption of light cigarettes is not associated with a lower detrimental effect on
endothelial dysfunction. Light cigarettes consumption should not be considered a valid alternative to
smoking cessation.
Funding: Research was supported in part by Philip Morris USA Inc. and Philip Morris International
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
B. Frigerio, S. Castelnuovo, M. Amato, A. Ravani, E. Tremoli, C. Sirtori, D. Baldassarre
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