Hemostatic variables as risk factors for carotid intima-media thickness progression in patients with pheripheral arterial disease
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Data di Pubblicazione:
1995
Citazione:
Hemostatic variables as risk factors for carotid intima-media thickness progression in patients with pheripheral arterial disease / D. Baldassarre, E. Tremoli, E. Cofrancesco, C. Boschetti. ((Intervento presentato al 1. convegno INTERNATIONAL SYMPOSIUM, WATCHING THE RISK: FROM THE ARTERIAL WALL THICKENING TO CLINICAL SYMPTOM tenutosi a Paris nel 1995.
Abstract:
Background: Changes in common carotid intima-media thickness
(CC-IMT), as measured by B-mode ultrasonography, have been used
in both population studies and clinical trials to seek risk factors for
early atherosclerosis progression and have already been associated
with age, high low density lipoprotein cholesterol, leukocytes,
hemoglobin, and fibrinogen.
Objective: To assess the relations between baseline hemostatic and
Conventional risk factors and CC-IMT changes over 16 months
(delta CC-IMT) in 64 peripheral arterial disease (PAD) patients randomly
selected from the prospective PLAT study (1).
Design: Samples from 24 (37.5%) patients who presented an
increase of CC-IMT during the follow-up period were compared with
those from 40 (62.5%) in whom CC-IMT remained unchanged during
the same time frame.
Results: Conventional risk factors and coagulation variables were
similar in the two groups except for higher vWF:Ag (178.3±53.6 vs
141.2±53.7%, p=0.01) and FVII (133.9±36.4 vs 107.0±27.3%,
p=0.001) in the patients with increased CC-IMT. Delta CC-IMT correlated
positively with plasma levels of FVII (r=0.31, p<0.01) and vWF
(r=0.31, p<0.01). Multiple stepwise regression analysis identified FVII
as the only independent variable associated with positive changes
of CC-IMT (r=0.83, r2=10.6, p=0.01).
Conclusions: High FVII and vWF:Ag might be risk factors for the
progression of early carotid atherosclerosis in PAD patients.
1. Atherosclerosis, 1991;90:109-118.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Keywords:
Carotid atherosclerosis, hemostatic variables, conventional risk factors, peripheral arterial disease
Elenco autori:
D. Baldassarre, E. Tremoli, E. Cofrancesco, C. Boschetti
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