Data di Pubblicazione:
1991
Citazione:
Impaired efficacy of selective LDL-apheresis in primary biliary cirrhosis / G. Busnach, G. Franceschini, G. Chiesa, B. Brando, A. Cappelleri, L. Isa, L. Minetti. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - 14:4(1991 Apr), pp. 246-250.
Abstract:
Low-density lipoprotein apheresis (LDL-apheresis) was done with either cascade filtration (DF) or dextran sulfate cellulose adsorption (DSC) in a patient with primary biliary cirrhosis who developed severe dyslipidemia associated with cholestasis and accumulation of lipoprotein-X (LP-X). The extracorporeal treatment was initially performed weekly, and resulted in a sharp drop in total cholesterol from 1038 to 430 mg/dl. During the next four months the patient was treated every 10-15 days, and pre-apheresis cholesterol levels were maintained between 438 and 505 mg/dl, until an orthotopic liver transplantation was successfully performed. With semi-selective DF a mean 47.1% of total cholesterol was removed per procedure compared to 30.0% with DSC, although the volume of treated plasma was 38.0 vs 49.9 ml/kg body weight. The changes in plasma cholesterol levels during DSC and DF showed that the kinetics of cholesterol removal were similar with both techniques, but the efficacy differed; DF removed both LDL and LP-X from plasma, whereas DSC selectively lowered the LDL content. Cascade filtration may therefore be considered as a first-choice treatment for patients with LP-X accumulation due to cholestasis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Filtration ; Blood Component Removal ; Humans ; Dextran Sulfate ; Adult; Cholesterol ; Lipoproteins, LDL ; Liver Cirrhosis, Biliary ; Male
Elenco autori:
G. Busnach, G. Franceschini, G. Chiesa, B. Brando, A. Cappelleri, L. Isa, L. Minetti
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