A rapid improved method for gamma- spectrometric determination of 202Tl impurities, in [201Tl]-labelled radiopharmaceuticals
Articolo
Data di Pubblicazione:
2002
Citazione:
A rapid improved method for gamma- spectrometric determination of 202Tl impurities, in [201Tl]-labelled radiopharmaceuticals / M. Bonardi, F. Groppi, C. Birattari. - In: APPLIED RADIATION AND ISOTOPES. - ISSN 0969-8043. - 57:5(2002), pp. 647-655.
Abstract:
Despite the cyclotron production method and the efficiency of the radiochemical procedures adopted, the long-lived radio-isotopic impurity 202Tl is always present in [201Tl]-labelled radio-pharmaceuticals, together with other short-lived impurities like, 200Tl. Rapid determination of the 202Tl impurity, can be achieved using HPGe gamma spectrometry and a detector shielded by a 5 mm thick envelope of lead. In this way, dead-time correction errors, Compton and X-ray background, are very efficiently avoided and suppressed. The same method could be applied routinely in nuclear medicine, to determine the radioisotopic purity of 201Tl by means of an ionisation chamber dose calibrator.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
γ-spectrometry; 201Tl; 202Tl impurity; Absorption; Dead time; Sample shielding
Elenco autori:
M. Bonardi, F. Groppi, C. Birattari
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