Tissue factor A-603G genotype associates with carotid intima-media thickness in subjects undergoing cardiovascular risk prevention
Abstract
Data di Pubblicazione:
2006
Citazione:
Tissue factor A-603G genotype associates with carotid intima-media thickness in subjects undergoing cardiovascular risk prevention / K. Gertow, D. Colnago, M. Amato, J.P. Werba, D. Baldassarre, M. Camera, E. Tremoli. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 16:1(2006), pp. S10-S10. ((Intervento presentato al 20. convegno CONGRESSO DELLA SOCIETÀ ITALIANA PER LO STUDIO DELL’ATEROSCLEROSI tenutosi a Bologna nel 2006.
Abstract:
Tissue factor (TF), initiator of coagulation, is also ascribed a non-hemostatic
function in atherosclerosis development. Polymorphisms in the TF gene promoter
have been shown to modulate the expression of TF, and thus perhaps
also its role in atherosclerosis. Hence, this study investigated associations
between TF promoter genotype and carotid intima-media thickness (IMT), a
well-established marker of atherosclerosis. The TF A-603G polymorphism and
carotid IMT was analyzed in 324 patients undergoing primary and secondary
cardiovascular risk prevention. Subjects were 60.5±8.4 years old, 80% were
male, and 77% were undergoing secondary prevention with a history of
atherosclerotic disease. Both mean and maximum carotid IMT (measured at
the common carotid, bifurcation, and internal carotid) differed significantly
according to A-603G genotype, being highest in -603A/A (n=95), intermediate
in A/G (n = 164) and lowest in G/G (n = 65) (mean IMT: A/A 1.31±0.37 nm,
A/G 1.28±0.33mm, G/G 1.22±0.35 mm; max IMT: A/A 2.35±0.91 mm,
A/G 2.25±0.84mm, G/G 2.15+0.97 mm; both p<0.05; tested for tend;
adjusted for age, gender, smoking habits, and anti-hypertensive treatment.
In summary, a significant association between TF promoter genotype and
carotid IMT was observed, maybe mediated via altered TF expression levels in
the circulation or within the carotid vessel wall. These findings support a role of
TF in the atherosclerotic process, beyond its role in hemostasis and thrombosis,
thus implicating TF not only in thrombotic complications of atherosclerotic
disease, but also in plaque progression.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
K. Gertow, D. Colnago, M. Amato, J.P. Werba, D. Baldassarre, M. Camera, E. Tremoli
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