Lack of association between hepatotropic transfusion transmitted virus infection and oral lichen planus in British and Italian populations
Articolo
Data di Pubblicazione:
2001
Citazione:
Lack of association between hepatotropic transfusion transmitted virus infection and oral lichen planus in British and Italian populations / C. Bez, R. Hallet, M. Carrozzo, G. Lodi, S. Gandolfo, A. Carrassi, C. Scully, S. Porter. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - 145:6(2001), pp. 990-993.
Abstract:
BACKGROUND: A possible association between oral lichen planus (OLP) and chronic
hepatic disease has been found in some populations, although this is probably
geographically influenced. In 1997 a new hepatotropic virus, transfusion
transmitted virus (TTV), was identified but has not been studied in relation to
OLP.
OBJECTIVE: The present investigation evaluated the genoprevalence of TTV DNA in
the sera of British and Italian patients suffering from OLP using two different
sets of primers to identify TTV subgenomic DNA.
METHODS: Study groups comprised 40 adult subjects (21 British, 19 Italian) with
OLP. For each country, two control groups, a disease-control group and a
healthy-control group, were included. The presence of TTV DNA in the sera of
patients and control subjects was assessed using two different polymerase chain
reactions (PCR) and DNA sequence analysis.
RESULTS: Statistical analysis did not reveal evidence of any association between
TTV infection and OLP or country of residence.
CONCLUSION: An association between TTV and OLP is unlikely.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
C. Bez, R. Hallet, M. Carrozzo, G. Lodi, S. Gandolfo, A. Carrassi, C. Scully, S. Porter
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