Efficient synthesis of an enantiopure beta-lactam as an advanced precursor of thrombin and tryptase inhibitors
Articolo
Data di Pubblicazione:
2003
Citazione:
Efficient synthesis of an enantiopure beta-lactam as an advanced precursor of thrombin and tryptase inhibitors / R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi, F. Maggioni, A. Puglisi. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 68:7(2003), pp. 2952-2955. [10.1021/jo020617u]
Abstract:
A new and efficient synthesis of a beta-lactam that is an advanced precursor of inhibitors of thrombin and tryptase is reported. The reaction sequence is based on the use of an inexpensive enantiomerically pure starting material and is designed to allow access to both enantiomers of the target molecules by epimerization of a side-product obtained along the synthesis. An improved procedure for the epimerization step that takes advantage of the use of a polymer-supported and recyclable phase-transfer catalyst is described.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
R. Annunziata, M. Benaglia, M. Cinquini, F. Cozzi, F. Maggioni, A. Puglisi
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