Data di Pubblicazione:
1987
Citazione:
Correlates of plasma atrial natriuretic factor in health and hypertension / P. Montorsi, G. Tonolo, J. Polonia, D. Hepburn, A. M. Richards. - In: HYPERTENSION. - ISSN 0194-911X. - 10:6(1987 Dec), pp. 570-6-576. [10.1161/01.HYP.10.6.570]
Abstract:
Plasma concentrations of atrial natriuretic factor (ANF) were compared in normotensive subjects and subjects with untreated, uncomplicated essential hypertension (n = 21 pairs) matched for age, sex, and race. Plasma peptide values were slightly greater (45 +/- 3 vs 36 +/- 3 pg/ml; p less than 0.05) in the hypertensive group. On univariate analysis, age (r = 0.52, n = 47, p less than 0.001) and creatinine clearance (r = -0.30, n = 47, p less than 0.05) were significantly related to plasma ANF concentrations, but arterial pressure was not (r = 0.14, n = 47), in an extended group of normal subjects. In contrast, plasma ANF values were related to arterial pressure in both an extended group of subjects with untreated essential hypertension (r = 0.54, n = 38, p less than 0.001) and in our total heterogeneous pool of hypertensive patients (r = 0.46, n = 79, p less than 0.001), but weak positive associations with age and inverse relationships with creatinine clearance were not statistically significant in either hypertensive group. Similar weak inverse relationships between plasma ANF values and renin-angiotensin-aldosterone system activity were found in both normal and hypertensive subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Atrial Natriuretic Factor; Age Factors; Blood Pressure; Humans; Adult; Renin-Angiotensin System; Middle Aged; Cardiomegaly; Male; Female; Hypertension
Elenco autori:
P. Montorsi, G. Tonolo, J. Polonia, D. Hepburn, A.M. Richards
Link alla scheda completa: