Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection
Articolo
Data di Pubblicazione:
1995
Citazione:
Disappearance of cryoglobulins and remission of symptoms in a patient with HCV-associated type II mixed cryoglobulinemia after HIV-1 infection / S. Antinori, L. Galimberti, S. Rusconi, G. Zehender, R. Esposito, M. Galli. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - 13:Suppl. 13(1995), pp. S157-S159. ((Intervento presentato al convegno Hepatitis C virus and cryoglobulinemia tenutosi a Milano nel 1994.
Abstract:
Objective. We report the case of a woman with long-lasting mixed cryoglobulinemic syndrome, who experienced clinical and laboratory remission of her cryoglobulinemia after becoming infected with human immunodeficiency virus and developing HIV-1 induced immunosuppression.
Methods. Serum cryoglobulin concentrations and the CD4+ cell count were monitored every three months.
Results. After the diagnosis of HIV-1 infection, the immunological status of the patient was constantly depressed (CD4+ cell count dropping from 337/mu L in January 1991 to 21/mu L in June 1994). Serum cryoglobulins were persistently absent over 43 months of follow-up, despite the presence of HCV-RNA,. Conclusion. In this case, HIV-1 induced immunodeficiency seems to be responsible for the remission of the cryoglobulin syndrome and the disappearance of serum cryoglobulins. These findings indicate that CD4+ T lymphocytes may play a role in regulating the activity of cryoprecipitating rheumatoid factor secreting B cell clones.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
mixed cryoglobulinemia ; HIV-1 infection ; CD4+ cells depletion ;
Elenco autori:
S. Antinori, L. Galimberti, S. Rusconi, G. Zehender, R. Esposito, M. Galli
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