Coronary adrenergic hyperreactivity in patients with syndrome X and abnormal electrocardiogram at rest
Articolo
Data di Pubblicazione:
1991
Citazione:
Coronary adrenergic hyperreactivity in patients with syndrome X and abnormal electrocardiogram at rest / P. Montorsi, F. Fabbiocchi, A. Loaldi, L. Annoni, A. Polese, N. De Cesare, M. Guazzi. - In: THE AMERICAN JOURNAL OF CARDIOLOGY. - ISSN 0002-9149. - 68:17(1991 Dec 15), pp. 1698-703-1703.
Abstract:
Syndrome X is characterized by an abnormal vasomotility of coronary microvessels. It is unknown whether the presence of an ischemic-like pattern in the electrocardiogram at rest (T-wave inversion) reflects a more severe vasomotion disturbance. Changes in coronary sinus flow (thermodilution) and epicardial vessel diameter (quantitative angiography) during adrenergic activation were measured with a standard cold pressor test in patients with syndrome X whose electrocardiogram at rest was normal (group 1: 17 patients) or showed stable, symmetrically inverted T waves (group 2: 22 patients). Cold pressor test increased mean blood pressure and rate-pressure product to a similar extent in both groups, increased coronary sinus flow in group 1 (88 +/- 29 to 119 +/- 36 ml/min; p less than 0.05) and not in group 2 (109 +/- 37 vs 104 +/- 36 ml/min; p = not significant), and decreased coronary resistance in group 1 (1.38 +/- 0.42 to 1.19 +/- 0.38 mm Hg/ml/min; p less than 0.05) and augmented it in group 2 (1.06 +/- 0.32 to 1.28 +/- 0.43 mm Hg/ml/min; p less than 0.02). During cold stimulus, the proximal and middle segments of epicardial arteries showed negligible changes in their lumen, whereas the distal segment dilated in group 1 (1.81 +/- 0.27 to 2.01 +/- 0.32 mm; p less than 0.05) and constricted in group 2 (1.82 +/- 0.12 to 1.62 +/- 0.20 mm; p less than 0.05). Differences in coronary hemodynamic and angiographic responses between the groups were statistically significant (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adrenergic Fibers; Cardiac Output; Vascular Resistance; Blood Pressure; Coronary Vessels; Humans; Coronary Circulation; Angina Pectoris; Cold Temperature; Vasomotor System; Heart Rate; Propranolol; Syndrome; Electrocardiography; Middle Aged; Female; Male
Elenco autori:
P. Montorsi, F. Fabbiocchi, A. Loaldi, L. Annoni, A. Polese, N. De Cesare, M. Guazzi
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