Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: a t(8;21)-Kit mutant model for acute myeloid leukemia
Articolo
Data di Pubblicazione:
2002
Citazione:
Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: a t(8;21)-Kit mutant model for acute myeloid leukemia / A. Beghini, I. Magnani, C. B. Ripamonti, L. Larizza. - In: HEMATOLOGY JOURNAL. - ISSN 1466-4860. - 3:3(2002), pp. 157-163. [10.1038/sj.thj.6200168]
Abstract:
A subset of AML-M2/M4Eo patients has been shown to carry c-kit mutations suggesting that myelomonoblastic leukemia cells, disrupting core binding factor through t(8;21) or inv(16) chromosomal rearrangements, have a common differentiation stage suitable to c-kit mutation. In rare core binding factor leukemia patients an increased dosage of a mutated Asp816(Tyr/Val) kit allele is achieved through nonrandom duplication of chromosome 4 where the c-kit gene is located.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Activating mutation; Core binding factor; Gene amplification; Kasumi-1; KIT
Elenco autori:
A. Beghini, I. Magnani, C.B. Ripamonti, L. Larizza
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