Data di Pubblicazione:
2012
Citazione:
Click synthesis of a triazole-based inhibitor of Met functions in cancer cells / F. Colombo, C. Tintori, A. Furlan, S. Borrelli, M.S. Christodoulou, R. Dono, F. Maina, M. Botta, M. Amat, J. Bosch, D. Passarella. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 22:14(2012), pp. 4693-4696.
Abstract:
The use of Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition permitted the synthesis of a new compound that is able to inhibit the HGF-induced scattering of MDCK (epithelial cells) and in vitro tumorigenesis of H1437 (non-small-cell lung cancer) and GTL-16 (human gastric carcinoma). In agreement with biochemical and biological results, docking studies within the ATP binding site of Met suggested for the new synthesized compound a binding mode similar to that of the active compound Triflorcas previously reported.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
anticancer compounds; click chemistry; Cu(I)-catalyzed; Inhibition of HGF-induced scattering
Elenco autori:
F. Colombo, C. Tintori, A. Furlan, S. Borrelli, M.S. Christodoulou, R. Dono, F. Maina, M. Botta, M. Amat, J. Bosch, D. Passarella
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