FUNCTIONAL AND BIOCHEMICAL MODIFICATIONS OF LUNG BETA-ADRENOCEPTORS AFTER INVIVO DESENSITIZATION - PREVENTION BY INDOMETHACIN
Articolo
Data di Pubblicazione:
1986
Citazione:
FUNCTIONAL AND BIOCHEMICAL MODIFICATIONS OF LUNG BETA-ADRENOCEPTORS AFTER INVIVO DESENSITIZATION - PREVENTION BY INDOMETHACIN / M. FANO, M. ABBRACCHIO, F. CATTABENI, L. DAFFONCHIO, A. HERNANDEZ, C. OMINI. - In: JOURNAL OF AUTONOMIC PHARMACOLOGY. - ISSN 0144-1795. - 6:1(1986), pp. 47-51.
Abstract:
1 Desensitization of lung β-adrenoreceptors induced by 4 day in vivo isoprenaline administration to rats has been investigated both from a functional and a biochemical viewpoint. 2 Chronic isoprenaline treatment significantly reduced the relaxing activity of the β-agonist when tested ex vivo in lung parenchymal strips and also impaired the adenylate-cyclase system. Moreover, the desensitization procedure decreased by about 30% β-adrenoreceptor number. 3 In vivo indomethacin treatment prevented the loss of pharmacological responsiveness of the tissue to isoprenaline and restored basal adenylate-cyclase activity. 4 These data indicate that in vivo isoprenaline administration actually leads to pulmonary β-adrenoreceptor desensitization. The involvement of arachidonic acid metabolites in this phenomenon is also discussed.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
M. FANO, M. ABBRACCHIO, F. CATTABENI, L. DAFFONCHIO, A. HERNANDEZ, C. OMINI
Link alla scheda completa: