Adenosine A(3) receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A(3) antagonists
Articolo
Data di Pubblicazione:
1997
Citazione:
Adenosine A(3) receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A(3) antagonists / Y. Yao, Y. Sei, M. Abbracchio, J. Jiang, Y. Kim, K. Jacobson. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 232:2(1997), pp. 317-322.
Abstract:
The effects of novel, selective adenosine (ADO) A3 receptor antagonists of diverse structure on cells of the human HL-60 leukemia and U-937 lymphoma cell lines were examined. Both 3-ethyl 5-benzyl 2-methyl-6-phenyl-4-phenylethynyl-1,4-(±)-dihydropyridine- 3,5-dicarboxylate (MRS 1191, 0.5 μM) and 6-carboxymethyl-5,9- dihydro-9-methyl-2-phenyl-[1,2,4]-triazolo[5,1-a][2,7]naphthyridine (L-249313, 0.5 μM) induced apoptotic cell death and expression of bak protein. Low concentrations of the A3 receptor agonist 2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide (Cl-IB-MECA, 10 nM or 1 μM) protected against antagonist-induced cell death. At concentrations ≤10 μM, the agonist alone produced apoptosis and bak expression in various cell lines. It is suggested that there exists a tonic low level of A3 receptor activation, possibly induced by release of endogenous adenosine, that results in cell protection.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
Y. Yao, Y. Sei, M. Abbracchio, J. Jiang, Y. Kim, K. Jacobson
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