NMDA receptor subunits are phosphorylated by activation of neurotrophin receptors in PSD of rat spinal cord
Articolo
Data di Pubblicazione:
2001
Citazione:
NMDA receptor subunits are phosphorylated by activation of neurotrophin receptors in PSD of rat spinal cord / M.M.G. Di Luca, F. Gardoni, A. Finardi, S. Pagliardini, F. Cattabeni, G. Battaglia, C. Missale. - In: NEUROREPORT. - ISSN 0959-4965. - 12:6(2001), pp. 1301-1305.
Abstract:
We have investigated the distribution of NMDA and neurotrophin receptor systems and their reciprocal interactions in post-synaptic densities (PSD) purified from spinal cord. NMDA receptor subunits, trkA and trkB, but not trkC, were present in spinal cord PSD. The incubation of PSD with BDNF and NGF induced the phosphorylation of NR2A and B subunits. This phosphorylation was counteracted by antibodies directed against the catalytic domain of trkA and trkB receptors and by genistein. These results suggest the existence of a previously unexplored cross-talk between neurotrophins and NMDA receptors in rat spinal cord neurons
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Neurotrophin receptors; NMDA; Phosphorylation; Postsynaptic density; Spinal cord
Elenco autori:
M.M.G. Di Luca, F. Gardoni, A. Finardi, S. Pagliardini, F. Cattabeni, G. Battaglia, C. Missale
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