Data di Pubblicazione:
1990
Citazione:
GLIBENCLAMIDE AND TOLBUTAMIDE IN HUMAN SERUM - RAPID MEASUREMENT OF THE FREE FRACTION / C.ARCELLONI, I. FERMO, A. CALDERARA, M. PACCHIONI, A.E. PONTIROLI, R. PARONI. - In: JOURNAL OF LIQUID CHROMATOGRAPHY. - ISSN 0148-3919. - 13:1(1990), pp. 175-189.
Abstract:
A rapid and reproducible procedure to evaluate the
glibenclamide and tolbutamide free fraction in serum was
developed. The ultrafiltration technique was used, employing
disposable filter units (Centricon 30, Amicon) with 3O.000 MW cutoff.
In order to obtain the maximum filtration recovery (l-01+33)
the pretreatment of membranes with 0.1 M sodium hydroxide and
biilistilled water rdas necessary. Results on the effect of
tiaprofenic acid, an antiinflammatory non steroÍdal agent, on
glibenclamide and tolbutamide levels in maturity onset diabetic
patients are reported. Neither pharmakokinetic parameters, nor
the free fraction of sulphonylureas were significantly changed
after tiaprofenic acid treatment, thus excluding the rIsk of
pharmacological interactions .
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Glibenclamide; Tolbutamide; serum; hypoglicemia; diabetes; pharmacokinetics
Elenco autori:
C.ARCELLONI, I. FERMO, A. CALDERARA, M. PACCHIONI, A.E. PONTIROLI, R. PARONI
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