Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration
Articolo
Data di Pubblicazione:
2003
Citazione:
Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration / G. Vitale, G.A. Lupoli, A. Ciccarelli, A. Lucariello, M.R. Fittipaldi, F. Fonderico, A. Panico, G. Lupoli. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - 88:3(2003), pp. 1319-1322.
Abstract:
Recombinant human TSH (rhTSH) has been proposed as an alternative method to the withdrawal of thyroid hormones in the follow-up of differentiated thyroid cancer. The aim of the present study was to evaluate the influence of several demographic and anthropometric parameters [age, body weight, height, body mass index, and body surface area (BSA)] on serum peak TSH levels after rhTSH administration. rhTSH was administered to 112 patients with differentiated thyroid carcinoma according to the conventional two-dose schedule (0.9 mg/d). Serum TSH levels were measured 24 h before and after the first administration of rhTSH, and then 24, 48, and 72 h after the second administration of rhTSH. In one severely obese patient, serum peak TSH values did not reach a valid stimulation range. Serum peak TSH levels were negatively related to body weight (r = -0.69; P < 0.0001), body mass index (r = -0.51; P < 0.0001), and BSA (r = -0.72; P < 0.0001). In a multivariate regression analysis including demographic and anthropometric variables, only BSA was independently associated to serum peak TSH concentrations (standardized β coefficient = -0.721; P < 0.0001). In conclusion, body size seems to influence serum peak TSH levels after rhTSH administration. Future studies should evaluate the possibility of using personalized rhTSH doses, adjusted in relation to BSA.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Vitale, G.A. Lupoli, A. Ciccarelli, A. Lucariello, M.R. Fittipaldi, F. Fonderico, A. Panico, G. Lupoli
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