Data di Pubblicazione:
1993
Citazione:
EFFICIENT PRODUCTION OF THE CYCLOSPORINE METABOLITE AM1 BY RABBIT HEPATIC-ENZYMES / R. PARONI, I. FERMO, L. IAVARONE, L.M. DELPUPPO, L. DEANGELIS, M. KIENLE. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 28:1(1993 Jul), pp. 73-84.
Abstract:
We describe here conditions for the in vitro preparation of the main metabolite of
cyclosporin A, namely AM1, with rabbit liver enzymes. The compound was
purified and was identified by comparison with the metabolite isolated from urine
of rats treated with [3H]CsA and by its Mass-Spectrometry Fast Ion Bombardment
(MS-FIB) and IHNMR spectra. The procedure is simple and with the enzyme
fraction derived from one rabbit liver 34 mg of the pure metabolite can be
obtained.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
CYCLOSPORINE-A; CYCLOSPORINE METABOLITES; AM1; MASS-SPECTROMETRY FAST ION BOMBARDMENT (MS-FIB); H-1NMR; BLOOD; TISSUES; URINE; BILE
Elenco autori:
R. PARONI, I. FERMO, L. IAVARONE, L.M. DELPUPPO, L. DEANGELIS, M. KIENLE
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