Acute and chronic treatments with citalopram lower somatostatin levels in rat brain striatum through different mechanisms
Articolo
Data di Pubblicazione:
1997
Citazione:
Acute and chronic treatments with citalopram lower somatostatin levels in rat brain striatum through different mechanisms / E. Prosperini, M. Rizzi, F. Fumagalli, G. Tarizzo, R. Samanin, C. Bendotti. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 69:1(1997), pp. 206-213.
Abstract:
The suggestion that somatostatin is involved in the pathophysiology of obsessive-compulsive disorder and the evidence that selective serotonin reuptake inhibitors show significant antiobsessional effect prompted us to examine the effect of citalopram, a selective and potent serotonin reuptake inhibitor, on the somatostatinergic system in different brain regions of the rat. A single intraperitoneal injection of 10 mg/kg citalopram significantly reduced somatostatin levels in the striatum and nucleus accumbens after 4 but not 1, 8, or 24 h. No changes were found in hippocampus. In addition, we found that the K+-evoked overflow of somatostatin-like immunoreactivity from striatal slices was significantly increased 1 h after a single injection of citalopram and was still higher, although not significantly, 4 h after the drug injection. Levels of preprosomatostatin mRNA were unchanged in striatum and accumbens 1 and 4 h after a single drug administration. In rats treated with citalopram (10 mg/kg i.p.) twice daily for 14 days, the levels of somatostatin and its mRNA were significantly decreased in the striatum but not in other brain regions 24 h after the last dose. No change was found in the basal or K+-evoked overflow of somatostatin-like immunoreactivity at 1, 4, and 24 h after the last drug injection. These results suggest that acute and chronic treatment with citalopram reduces somatostatin levels in striatum by different mechanisms. Whereas a single dose of the drug reduces somatostatin levels by increasing the release of the peptide, repeated drug treatment reduces the biosynthesis of somatostatin.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
5-Hydroxytryptamine uptake inhibitors; Basal ganglia; Citalopram; Obsessive- compulsive disorder; Somatostatin
Elenco autori:
E. Prosperini, M. Rizzi, F. Fumagalli, G. Tarizzo, R. Samanin, C. Bendotti
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