Data di Pubblicazione:
1994
Citazione:
OPEN-CHAIN PEPTIDES OBTAINED BY ACIDIC HYDROLYTIC CLEAVAGE OF CYCLOSPORINE-A / F. MAGNI, C. ARCELLONI, R. PARONI, I. FERMO, P.A. BONINI, M. DELPUPPO, A. MANZOCCHI, MG KIENLE. - In: BIOLOGICAL MASS SPECTROMETRY. - ISSN 1052-9306. - 23:8(1994 Aug), pp. 514-518.
Abstract:
Hydrolysis of cyclosporin A (CsA) was studied in order to clarify the still undefined point of attack of the acidic degradation. Among ether extractable and water-soluble products formed from CsA in HCl, two open-chain peptides were isolated by high-performance liquid chromatography which were identified as the deca- and nonapeptides deriving from CsA through the hydrolytic cleavage of amino acid residue 11 and both residues 11 and 10, respectively. Identification was carried out by fast atom bombardment tandem mass spectrometry.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
METABOLITE; DEGRADATION; KINETICS
Elenco autori:
F. MAGNI, C. ARCELLONI, R. PARONI, I. FERMO, P.A. BONINI, M. DELPUPPO, A. MANZOCCHI, MG KIENLE
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