High density lipoprotein and coronary heart disease: insights from mutations leading to low high density lipoprotein
Articolo
Data di Pubblicazione:
1997
Citazione:
High density lipoprotein and coronary heart disease: insights from mutations leading to low high density lipoprotein / L. Calabresi, G. Franceschini. - In: CURRENT OPINION IN LIPIDOLOGY. - ISSN 0957-9672. - 8:4(1997), pp. 219-224.
Abstract:
Hypoalphalipoproteinemia can result from defects in the genes encoding apolipoprotein A-I, the major protein component of HDL, or enzymes that are critical for the formation/maturation of mature HDL. Recent information contradicts earlier findings, suggesting that most of the affected subjects are at increased risk of developing coronary heart disease, independent of the mutated gene. A possible exception is represented by mutations in the apolipoprotein A-I gene leading to structural variants, that might even exert a protective effect against atherosclerosis.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
L. Calabresi, G. Franceschini
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