Data di Pubblicazione:
1996
Citazione:
Ceftazidime kinetics of diffusion in inoculated agar plates / C. Arcelloni, R. Paroni, M. Basile, P.A. Bonini, R. Vaiani. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 40:5(1996 May), pp. 1280-1281.
Abstract:
The ceftazidime concentration in agar plates inoculated with Pseudomonas aeruginosa was determined by high-performance liquid chromatography at fixed points (3, 6, 9, 12, and 15 mm) from the disk center and at fixed times (2, 4, 6, 16, and 24 h) to study the antibiotic kinetics of diffusion. A statistical difference between the concentrations determined in the presence of microorganisms and in uninoculated plates after 16 and 24 h was evidenced and was probably ascribable to the drug hydrolysis carried out by the induced beta-lactamase.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
HPLC; agar diffusion test; reference methods
Elenco autori:
C. Arcelloni, R. Paroni, M. Basile, P.A. Bonini, R. Vaiani
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