Data di Pubblicazione:
1993
Citazione:
NUCLEAR HORMONE RECEPTORS AS TARGETS FOR NEW DRUG DISCOVERY / D. MCDONNELL, E. VEGETO, M. GLEESON. - In: BIO/TECHNOLOGY. - ISSN 0733-222X. - 11:11(1993), pp. 1256-1261.
Abstract:
There are two basic types of receptor transducing systems: those which utilize membrane bound receptors and are activated at the cell surface by the appropriate hormone and transmit their signal to the internae of the cell via a second messenger (i.e. cAMP), and those that utilize internal, cytoplasmic or nuclear receptors (intracellular receptors) which upon activation by hormones interact directly with DNA and alter the genetic program of a cell. This review focuses on the mechanism of action of these intracellular receptors and discusses how such an understanding is expected to facilitate the discovery of new therapeutic agents.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
D. MCDONNELL, E. VEGETO, M. GLEESON
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