Association between OLR1 K167N SNP and Intima Media Thickness of the Common Carotid Artery in the General Population
Articolo
Data di Pubblicazione:
2012
Citazione:
Association between OLR1 K167N SNP and Intima Media Thickness of the Common Carotid Artery in the General Population / I.M. Predazzi, G.D. Norata, L. Vecchione, K. Garlaschelli, F. Amati, L. Grigore, L. Cutuli, A. Pirillo, S. Tramontana, F. Romeo, G. Novelli, A.L. Catapano. - In: PLOS ONE. - ISSN 1932-6203. - 7:2(2012 Feb), pp. e31086.e31086.1-e31086.e31086.6.
Abstract:
BACKGROUND AND PURPOSE: The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent. Methods - We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).
RESULTS: Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers.
CONCLUSIONS: These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
I.M. Predazzi, G.D. Norata, L. Vecchione, K. Garlaschelli, F. Amati, L. Grigore, L. Cutuli, A. Pirillo, S. Tramontana, F. Romeo, G. Novelli, A.L. Catapano
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