Influence of some detoxification enzyme polymorphisms on cytogenetic biomarkers between individuals exposed to very low doses of 1,3-butadiene
Articolo
Data di Pubblicazione:
2009
Citazione:
Influence of some detoxification enzyme polymorphisms on cytogenetic biomarkers between individuals exposed to very low doses of 1,3-butadiene / N. Bukvic, P. Lovreglio, M. Fanelli, F.C. Susca, A. Ballini, P. Lastella, V. Foà, S. Fustinoni, L. Soleo, G. Guanti. - In: JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. - ISSN 1076-2752. - 51:7(2009), pp. 811-821. [10.1097/JOM.0b013e3181a88d7f]
Abstract:
Objective: To evaluate the variation of some biomarkers related to the level of
enzymatic activity dependent on the different polymorphisms. Methods: We studied
27 butadiene-exposed workers and 37 controls using different biomarkers of the
genotoxic effect. The genotypes were determined using polymerase chain reaction and
restriction fragment length polymorphism-polymerase chain reaction techniques; the
subjects were assigned to a specific group based on the microsomal epoxide hydrolase
(mEH) activity predicted by their genotype (low, intermediate, high). Results: The
studied biomarkers were not able to discriminate between exposed and control
individuals, but sister chromatid exchange (SCE) and high frequency cells were
influenced by smoking habits. Smokers having fast microsomal epoxide hydrolase
activity showed higher SCE frequency (7.61) respect to those presenting intermediate
(5.86) or slow (6.65) enzymatic activity. Conclusions: On the basis of these results,
can we suppose the existence of an “intermediate genotype” advantage (at least for
induction of SCE)?
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
1,3-butadiene, sister chromatide exchange ; genetic polymorphism of metabolic enzymes
Elenco autori:
N. Bukvic, P. Lovreglio, M. Fanelli, F.C. Susca, A. Ballini, P. Lastella, V. Foà, S. Fustinoni, L. Soleo, G. Guanti
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