Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics
Articolo
Data di Pubblicazione:
2001
Citazione:
Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics / A. Bernardi, D. Arosio, L. Manzoni, F. Micheli, A. Pasquarello, P. Seneci. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 66:19(2001 Sep 21), pp. 6209-6216.
Abstract:
The practical, stereoselective synthesis of the three diastereoisomeric 1,2-trans-dicarboxy-4,5-cyclohexanediols 1-3 (DCCHDs) is described, starting from a common precursor, easily available in both enantiomeric forms. The regioselective derivatization of all functional groups of 1 is also reported. The three DCCHDs are locked in a single chair conformation and thus can be used to mimic vicinally disubstituted monosaccharides of any relative configuration
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Molecular Mimicry ; Molecular Conformation ; Cyclohexanols ; Drug Design ; Monosaccharides
Elenco autori:
A. Bernardi, D. Arosio, L. Manzoni, F. Micheli, A. Pasquarello, P. Seneci
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