Data di Pubblicazione:
2011
Citazione:
Response of human pulps capped with PDGF. Pilot study / G. Pellegrini, C. Dellavia, P. Generali, C. Allievi, D. Re, G. Rasperini. ((Intervento presentato al 15. convegno Biennial Congress Of The European Society Of Endodontology tenutosi a Roma nel 2011.
Abstract:
Introduction: Growth factors showed the potential to promote odontoblast-
like cells differentiation and induce the formation of reparative dentine. Aim of this pilot study is to evaluate the pulp response
after capping procedure performed with PDGF BB. METHODOLOGY.
Two third molars (site A and site B) were treated. Class I cavities
were prepared and the exposed pulps were capped with cotton pellet
embedded in PDGF solution and fi lled. Teeth were extracted after
40 days and processed for routine histological examination. The hard
bridge formation and the infl ammatory pulp reaction were evaluated.
RESULTS. In site A, incomplete and thick dentine bridge formation
(mean thickness of 199.5um) was observed. The pulp tissue close to
the remaining exposed pulp was moderately disorganized with many
fi broblasts and few infl ammatory cells. In site B, incomplete dentin
bridge (mean thickness of 215um) covered part of the defect. The
pulp was overall normal but a limited area close to the dentin bridge
interruption, where a clot-like tissue with many fi broblasts and few
infl ammatory cells was observed. CONCLUSION. PDGF-BB does not
elicit infl ammatory response neither induces the extensive matrix
deposition and appears to be a safe pulp capping agent.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
G. Pellegrini, C. Dellavia, P. Generali, C. Allievi, D. Re, G. Rasperini
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