In vitro and ex vivo pharmacodynamics of selected non-steroidal anti-inflammatory drugs in equine whole blood
Articolo
Data di Pubblicazione:
2012
Citazione:
In vitro and ex vivo pharmacodynamics of selected non-steroidal anti-inflammatory drugs in equine whole blood / B. Cuniberti, R. Odore, R. Barbero, P.P. Cagnardi, P. Badino, C. Girardi, G. Re. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 191:3(2012), pp. 327-333. [10.1016/j.tvjl.2011.03.016]
Abstract:
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenases (COX), and the inhibition of
COX-2 rather than COX-1 can limit the onset of NSAID-related adverse effects. The pharmacodynamic
properties of eltenac, naproxen, tepoxalin, SC-560 and NS 398 in healthy horses were investigated using
an in vitro whole blood assay. To predict COX selectivity in clinical use, eltenac and naproxen were also
studied ex vivo after intravenous administration.
SC-560 acted as a selective COX-1 inhibitor, tepoxalin as a dual inhibitor with potent activity against
COX-1, and NS 398 as a preferential COX-2 inhibitor. Eltenac was a preferential COX-2 inhibitor
in vitro but un-selective in the ex vivo study. Naproxen maintained its non-selectivity both in vitro
and ex vivo. These findings have demonstrated that in vitro studies may not accurately predict in vivo
NSAID selectivity for COX and should be confirmed using an ex vivo whole blood assay
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Horse; Non-steroidal anti-inflammatory drugs; Pharmacodynamics; Whole blood assay
Elenco autori:
B. Cuniberti, R. Odore, R. Barbero, P.P. Cagnardi, P. Badino, C. Girardi, G. Re
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