Data di Pubblicazione:
2011
Citazione:
No association of DPP6 with amyotrophic lateral sclerosis in an Italian population / I. Fogh, S. D'Alfonso, C. Gellera, A. Ratti, C. Cereda, S. Penco, L. Corrado, G. Sorarù, B. Castellotti, C. Tiloca, S. Gagliardi, L. Cozzi, M.K. Lupton, N. Ticozzi, L. Mazzini, C.E. Shaw, A. Al-Chalabi, J. Powell, V. Silani. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 32:5(2011), pp. 966-967.
Abstract:
We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P= 0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Amyotrophic lateral sclerosis; Genome-wide association study; Polymorphism; Dipeptidyl-peptidase 6 (DPP6) gene
Elenco autori:
I. Fogh, S. D'Alfonso, C. Gellera, A. Ratti, C. Cereda, S. Penco, L. Corrado, G. Sorarù, B. Castellotti, C. Tiloca, S. Gagliardi, L. Cozzi, M.K. Lupton, N. Ticozzi, L. Mazzini, C.E. Shaw, A. Al-Chalabi, J. Powell, V. Silani
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