Data di Pubblicazione:
2006
Citazione:
Retinal toxicity of intravitreal triamcinolone acetonide: a morphological study / S.Y. Yu, F.M. Damico, F. Viola, D.J. Amico, L.H. Young. - In: RETINA. - ISSN 0275-004X. - 26:5(2006), pp. 531-536.
Abstract:
Purpose: To evaluate the morphologic effects of intravitreal triamcinolone acetonide
(TA) on rabbit retina.
Methods: Intravitreal injections of 0.5 mg, 1 mg, 4 mg, 8 mg, and 20 mg of TA
(Kenalog-40; Bristol-Myers Squibb, Princeton, NJ) in 0.1 mL were given to pigmented
rabbits. For control, 0.1 mL of TA vehicle and saline were injected. Animals were killed on
day 14, and retinas were analyzed by light as well as electron microscopy.
Results: No ophthalmoscopic change was found. Eyes injected with 0.5 mg and 1 mg
of TA did not have morphologic abnormality. Eyes injected with 4 mg, 8 mg, and 20 mg
showed destruction of photoreceptor outer segments and migration of macrophage-like
cells in the subretinal space. Eyes injected with 20 mg showed more extensive damage
and increased pigment granules in the retinal pigment epithelium cells with large oil
droplets in the cytoplasm. Electron microscopy also showed loss of photoreceptor/retinal
pigment epithelium interdigitations. Eyes injected with vehicle or saline did not show
morphologic changes.
Conclusion: Single intravitreal injection of 0.5 mg or 1 mg of TA did not produce
morphologic retinal changes in pigmented rabbits. However, injections of 4 mg, 8 mg, and
20 mg of TA produced outer retina toxic effects. These findings suggest that long-term
retinal toxicity studies should be carried out, using single and repeated injections before
this therapy becomes more widely used.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antiinflammatory agents; Corticosteroids; Intravitreal drug delivery
Elenco autori:
S.Y. Yu, F.M. Damico, F. Viola, D.J. Amico, L.H. Young
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