Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) by 15-lipoxygenase-modified LDL in endothelial cells
Articolo
Data di Pubblicazione:
2011
Citazione:
Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) by 15-lipoxygenase-modified LDL in endothelial cells / A. Pirillo, A. Reduzzi, N. Ferri, H. Kuhn, A. Corsini, A.L. Catapano. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 214:2(2011 Feb), pp. 331-337.
Abstract:
OBJECTIVE: Lectin-like oxidized LDL receptor-1 (LOX-1), the endothelial receptor for OxLDL, is believed to be responsible for a number of OxLDL-induced effects in the endothelium.
METHODS AND RESULTS: In the present study we showed that LDL modified by 15-lipoxygenase (15LO-LDL), a form of minimally modified lipoprotein, beside its ability to induce pro-inflammatory responses such as oxidative stress and the expression of adhesion molecules, significantly increases LOX-1 expression in endothelial cells, both at transcriptional and at protein level. Such effect is likely to be mediated by p38 MAPK and NF-kB pathways. We then permanently overexpressed LOX-1 in an endothelial cell line and showed that 15LO-LDL were a ligand for LOX-1, and that the interaction LOX-1/15LO-LDL upregulated ICAM-1 surface expression.
CONCLUSION: Altogether these results indicate minimally modified LDL as a new inducer for LOX-1 expression and as a new ligand for LOX-1.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
LOX-1 ; LDL ; 15-Lipoxygenase ; Endothelial cells ; ICAM-1
Elenco autori:
A. Pirillo, A. Reduzzi, N. Ferri, H. Kuhn, A. Corsini, A.L. Catapano
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