Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors
Articolo
Data di Pubblicazione:
2011
Citazione:
Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors / A. Pinto, P. Conti, G. Grazioso, L. Tamborini, U. Madsen, B. Nielsen, C. De Micheli. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 46:2(2011), pp. 787-793. [10.1016/j.ejmech.2010.12.020]
Abstract:
The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
1,3-Dipolar cycloaddition; Glutamic acid; Ionotropic Glu receptors; Isoxazoline
Elenco autori:
A. Pinto, P. Conti, G. Grazioso, L. Tamborini, U. Madsen, B. Nielsen, C. De Micheli
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