Data di Pubblicazione:
2010
Citazione:
N-6-Alkyladenosines: synthesis and evaluation of in vitro anticancer activity / R. Ottria, S. Casati, E. Baldoli, J.A.M. Maier, P. Ciuffreda. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 18:23(2010), pp. 8396-8402. [10.1016/j.bmc.2010.09.030]
Abstract:
A series of adenosine analogues differently substituted in N-6-position were synthesized to continue our studies on the relationships between structure and biological activity of iPA. The structures of the compounds were confirmed by standard studies of H-1 NMR, MS and elemental analysis. These molecules were then evaluated for their anti-proliferative activity on bladder cancer cells. We found that some of these compounds possess anti-proliferative activity but have no effect on cell invasion and metalloprotease activity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Isopentenyladenosine ; cytokinins ; modified nucleosides; antitumor agents ; bladder carcinoma cells
Elenco autori:
R. Ottria, S. Casati, E. Baldoli, J.A.M. Maier, P. Ciuffreda
Link alla scheda completa: