Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aHpyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies
Articolo
Data di Pubblicazione:
2010
Citazione:
Synthesis of 3-Aryl/benzyl-4,5,6,6a-tetrahydro-3aHpyrrolo[3,4-d]isoxazole Derivatives: A Comparison between Conventional, Microwave-Assisted and Flow-Based Methodologies / S. Castellano, L. Tamborini, M. Viviano, A. Pinto, G. Sbardella, P. Conti. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 75:21(2010 Nov 05), pp. 7439-7442. [10.1021/jo1014323]
Abstract:
Two modern synthetic technologies to perform 1,3-dipolar cycloaddition reactions were compared. This study puts in evidence the power of microwave-assisted and flow-based methodologies compared to the conventional one in terms of reaction time and yield, and demonstrates the potential of flow chemistry in terms of time, automation, and scaling up opportunities.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
S. Castellano, L. Tamborini, M. Viviano, A. Pinto, G. Sbardella, P. Conti
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