Prevention of spontaneous mammary adenocarcinoma in HER-2/neu transgenic mice by foreign DNA
Articolo
Data di Pubblicazione:
2002
Citazione:
Prevention of spontaneous mammary adenocarcinoma in HER-2/neu transgenic mice by foreign DNA / L. Sfondrini, D. Besusso, C. Rumio, M. Rodolfo, S. Menard, A. Balsari. - In: THE FASEB JOURNAL. - ISSN 0892-6638. - 16:13(2002 Nov), pp. 1749-1754.
Abstract:
Unmethylated CpG-oligodeoxynucleotides (CpG-ODNs) are recognized as a 'danger signal' and are potent immunostimulators. To test whether tumors might be prevented by maintaining the innate immune system on continuous alert, proto-neu transgenic female mice, which develop spontaneous mammary tumors, were systemically treated with CpG-ODNs at 10-day intervals. Tumor incidence and number of tumors/mouse were significantly lower in treated mice compared with the control group. Moreover, CpG-ODN systemic treatment significantly reduced lung metastases induced by intravenous inoculation of N202.1A cells derived from a spontaneous mammary carcinoma. Growth of established tumors was modestly inhibited after CpG-ODN systemic treatment but strongly on peritumoral application. Our data indicate that systemic repeated injection of CpG-ODN to maintain the innate immune system on continuous alert prevents the onset of genetically determined tumors and confers tumor protection when the tumor load is low.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
CpG-oligodeoxynucleotides; Danger signal; Innate immunity; Murine tumors
Elenco autori:
L. Sfondrini, D. Besusso, C. Rumio, M. Rodolfo, S. Menard, A. Balsari
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