Identification of Minor Secondary Metabolites from the Latex of Croton lechleri (Muell-Arg) and Evaluation of Their Antioxidant Activity
Articolo
Data di Pubblicazione:
2008
Citazione:
Identification of Minor Secondary Metabolites from the Latex
of Croton lechleri (Muell-Arg) and Evaluation of Their
Antioxidant Activity / S. De Marino, F. Gala, F. Zollo, S. Vitalini, G. Fico, F. Visioli, M. Iorizzi. - In: MOLECULES. - ISSN 1420-3049. - 13:6(2008), pp. 1219-1229. [10.3390/molecules13061219]
Abstract:
Dragon’s blood (Sangre de drago), a viscous red sap derived from Croton
lechleri Muell-Arg (Euphorbiaceae), is extensively used by indigenous cultures of the
Amazonian basin for its wound healing properties. The aim of this study was to identify
the minor secondary metabolites and test the antioxidant activity of this sustance. A bioguided
fractionation of the n-hexane, chloroform, n-butanol, and aqueous extracts led to
the isolation of 15 compounds: three megastigmanes, four flavan-3-ols, three
phenylpropanoids, three lignans, a clerodane, and the alkaloid taspine. In addition to these
known molecules, six compounds were isolated and identified for the first time in the
latex: blumenol B, blumenol C, 4,5-dihydroblumenol A, erythro-guaiacyl-glyceryl-β-O-4’-
dihydroconiferyl ether, 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol and
floribundic acid glucoside. Combinations of spectroscopic methods (1H-, 13C- NMR and
2D-NMR experiments), ESI-MS, and literature comparisons were used for compound identification. In vitro antioxidant activities were assessed by DPPH, total antioxidant
capacity and lipid peroxidation assays. Flavan-3-ols derivatives (as major phenolic
compounds in the latex) exhibited the highest antioxidant activity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antioxidant activity; Croton lechleri; Euphorbiaceae; Latex; Sangre de drago; Secondary metabolites
Elenco autori:
S. De Marino, F. Gala, F. Zollo, S. Vitalini, G. Fico, F. Visioli, M. Iorizzi
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