Is M129V of PRNP gene associated with Alzheimer's disease? : a case-control study and a meta-analysis
Articolo
Data di Pubblicazione:
2006
Citazione:
Is M129V of PRNP gene associated with Alzheimer's disease? : a case-control study and a meta-analysis / R. Del Bo, M. Scarlato, S. Ghezzi, F. Martinelli Boneschi, C. Fenoglio, G. Galimberti, S. Galbiati, R. Virgilio, D. Galimberti, C. Ferrarese, E. Scarpini, N. Bresolin, G.P. Comi. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 27:5(2006), pp. 770.e1-770.e5.
Abstract:
The methionine/valine (M/V) polymorphism at codon 129 within the prion protein gene (PRNP) represents a known risk factor for Creutzfeldt-Jakob disease (CJD). Few authors reported also the effects of this polymorphism on the risk of Alzheimer's disease (AD), although with controversial results. To better clarify this issue, we performed a novel case-control study and a meta-analysis of published association studies between PRNP and AD. Our findings argue against PRNP as a susceptibility gene for developing AD in the Italian population but support the hypothesis that the V allele influences cognitive performances. The meta-analysis, revealed that Caucasian subjects homozygous at codon 129 had a 1.3-fold increased risk [95% CI: 1.0-1.6, p = 0.05] of developing AD compared to heterozygous individuals. We also observed that MM genotype and M allele represent a risk factor for AD, independently from the ethnic background, providing a significant but modest association between this polymorphism and AD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Prion protein gene; Alzheimer's disease; PRNP variability; APOE; Genetic risk factor; Meta-analysis
Elenco autori:
R. Del Bo, M. Scarlato, S. Ghezzi, F. Martinelli Boneschi, C. Fenoglio, G. Galimberti, S. Galbiati, R. Virgilio, D. Galimberti, C. Ferrarese, E. Scarpini, N. Bresolin, G.P. Comi
Link alla scheda completa: