Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype
Articolo
Data di Pubblicazione:
2009
Citazione:
Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype / S. Pellegrino, N. Ferri, N. Colombo, E. Cremona, A. Corsini, R. Fanelli, M.L. Gelmi, C. Cabrele. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 19:22(2009 Nov 15), pp. 6298-6302.
Abstract:
Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated α-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of α-actin and decreased Id protein levels
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Id proteins ; Protein domain recognition ; Helix–loop–helix ; Peptide dimerization ; Peptide mimic ; Solid-phase peptide synthesis ; Smooth muscle cell
Elenco autori:
S. Pellegrino, N. Ferri, N. Colombo, E. Cremona, A. Corsini, R. Fanelli, M.L. Gelmi, C. Cabrele
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