Data di Pubblicazione:
2006
Citazione:
Steroids and glial function / L. M. Garcia-Segura, R. C. Melcangi. - In: GLIA. - ISSN 0894-1491. - 54:6(2006), pp. 485-498.
Abstract:
Hormonal and locally produced steroids act in the nervous
system as neuroendocrine regulators, as trophic factors and
as neuromodulators and have a major impact on neural development
and function. Glial cells play a prominent role in
the local production of steroids and in the mediation of steroid
effects on neurons and other glial cells. In this review,
we examine the role of glia in the synthesis and metabolism
of steroids and the functional implications of glial steroidogenesis.
We analyze the mechanisms of steroid signaling on
glia, including the role of nuclear receptors and the mechanisms
of membrane and cytoplasmic signaling mediated
by changes in intracellular calcium levels and activation of
signaling kinases. Effects of steroids on functional parameters
of glia, such as proliferation, myelin formation, metabolism,
cytoskeletal reorganization, and gliosis are also
reviewed, as well as the implications of steroid actions on
glia for the regulation of synaptic function and connectivity,
the regulation of neuroendocrine events, and the response
of neural tissue to injury.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Dehydroepiandrosterone; Glucocorticoids; Pregnenolone; Sex steroids
Elenco autori:
L. M. Garcia-Segura, R. C. Melcangi
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