Growth factors and steroid hormones: a complex interplay in the hypothalamic control of reproductive functions
Articolo
Data di Pubblicazione:
2002
Citazione:
Growth factors and steroid hormones: a complex interplay in the hypothalamic control of reproductive functions / C. Melcangi, L. Martini, M. Galbiati. - In: PROGRESS IN NEUROBIOLOGY. - ISSN 0301-0082. - 67:6(2002), pp. 421-449.
Abstract:
The mechanisms through which LHRH-secreting neurons are controlled still represent a crucial and debated field of research in the neuroendocrine control of reproduction. In the present review, we have specifically considered two potential signals reaching these hypothalamic neurons: steroid hormones and growth factors. Examples of the relevant physiological role of the interactions between these two families of biologically acting molecules have been provided. In many cases, these interactions occur at the level of hypothalamic astrocytes, which are presently accepted as functional partners of the LHRH-secreting neurons. On the basis of the observations here summarized, we have formulated the hypothesis that a functional co-operation of steroid hormones and growth factors occurring in the hypothalamic astrocytic compartment represents a key factor in the neuroendocrine control of reproductive functions.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
steroids ; GnRH ; estrogen ; progesterone ; growth factor ; bFGF ; TGFbeta
Elenco autori:
C. Melcangi, L. Martini, M. Galbiati
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