Data di Pubblicazione:
2008
Citazione:
Mediterranean diet and cardioprotection: Wild artichoke inhibits metalloproteinase 9 / S. Bellosta, P. Bogani, M. Canavesi, C. Galli, F. Visioli. - In: MOLECULAR NUTRITION & FOOD RESEARCH. - ISSN 1613-4125. - 52:10(2008), pp. 1147-1152.
Abstract:
Metalloproteinases (MMPs) are zinc-dependent endopeptidases responsible for the hydrolysis of various component of extracellular matrix such as gelatin and collagen. MMPs, namely MMP-2 and MMP-9 correlate with cardiovascular events in patients. We sought to determine whether supplementation with polyphenol-rich Cynara cardunculus (wild artichoke, traditional component of the Mediterranean diet) modulates MMP-9 expression and activity in cell cultures. A fully characterized C. cardunculus extract was able to inhibit, in a dose-dependent manner, the gelatinolytic activity of secreted MMP-9 and both secretion and human MMP-9 promoter-driven transcription. Analysis by HPLC of the Cynara extract identified polyphenols such as luteolin, apigenin, and caffeic acid, among others. However, testing a mix of the individual components suggested that the inhibitory effects of C. cardunculus are due to minor constituent fraction(s) as a whole. In promoting the health benefits of the Mediterranean diet, the role of wild plants as important meal components deserves further reappraisal
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Antioxidants; Cardiovascular disease; Gelatinases; Mediterranean diet; Polyphenols
Elenco autori:
S. Bellosta, P. Bogani, M. Canavesi, C. Galli, F. Visioli
Link alla scheda completa: