Differential alterations in the ability of bovine neutrophils to generate extracellular and intracellular reactive oxygen species during the periparturient period
Articolo
Data di Pubblicazione:
2008
Citazione:
Differential alterations in the ability of bovine neutrophils to generate extracellular and intracellular reactive oxygen species during the periparturient period / M. Rinaldi, P. Moroni, M.J. Paape, D.D. Bannerman. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 178:2(2008 Nov), pp. 208-213. [10.1016/j.tvjl.2007.07.030]
Abstract:
The periparturient period of a dairy cow is associated with increased incidence and/or severity of certain infectious diseases, including mastitis. It is believed that the heightened physiological demands of calving and initiation of milk production contribute to a state of immunosuppression during this period. Previous studies have indicated that neutrophil production of reactive oxygen species (ROS), which is a critical element of the host innate immune response to bacterial infection, is impaired in the 1-2 week period following calving. However, whether there is comprehensive inhibition of ROS production or selective inhibition of particular ROS remains unknown. The present study provides evidence that neutrophils isolated from cows (n = 20) after calving have an increased capacity to generate intracellular ROS and an impaired ability to release extracellular superoxide anion and hydrogen peroxide.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Dairy cattle; Mastitis; Neutrophil; Parturition; Reactive oxygen species
Elenco autori:
M. Rinaldi, P. Moroni, M.J. Paape, D.D. Bannerman
Link alla scheda completa: