Data di Pubblicazione:
2002
Citazione:
Effect of prolonged gastric distension on motor function of LES and of proximal stomach / M. Allocca, M. Mangano, R. Penagini. - In: AMERICAN JOURNAL OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY. - ISSN 0193-1857. - 283:3(2002), pp. 677-680. [10.1152/ajpgi.00526.2001]
Abstract:
Gastric distension is a potent stimulus of transient lower esophageal sphincter (LES) relaxation. To investigate the time effect of prolonged gastric distension on the rate of transient LES relaxations, LES pressure, and the motor and sensory functions of the proximal stomach, we performed a continuous isobaric distension of the proximal stomach at the 75% threshold pressure for discomfort for 2 h in seven healthy subjects. A multilumen assembly incorporating a sleeve and an electronic barostat was used. The rate of transient LES relaxations (n/30 min) was constant during the first hour [4.1 ± 1.2 (0-30 min) and 5.4 ± 1.1 (30-60 min)] but markedly decreased (P < 0.05) in the second hour [2.1 ± 0.5 (60-90 min) and 2.3 ± 0.9 (90-120 min)], whereas LES pressure, baseline volume and volume waves within the gastric bag, hunger, and fullness did not change throughout the experiment. It is concluded that the rate of transient LES relaxations decreases with time during prolonged gastric distension, thus suggesting that this type of stimulus should not be used in sequential experimental conditions.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Barostat; Gastric tone; Lower esophageal sphincter pressure
Elenco autori:
M. Allocca, M. Mangano, R. Penagini
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